Protein Details: KCa4.2 (Calcium-activated potassium channel)
Protein ID
ICDB_Pro_1119
Protein Name
KCa4.2 (Calcium-activated potassium channel)
Gene Name
Kcnt2; Slick
Organism
Rattus norvegicus (Rat)
Length
1142 amino acids
AlphaFoldDB
AF-Q6UVM4-F1-model_v4.pdb
Function
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels . Channel activity is inhibited by ATP and by inhalation anesthetics; such as isoflurane. Inhibited upon stimulation of G-protein coupled receptors; such as CHRM1 and GRM1 (By similarity)
Sequence
PDB Structures
Ligand Binding
Binding Site
1032..1039
Disease
Location
Detected in brain; and at low levels in heart. Detected in brainstem; including auditory neurons such as the medial nucleus of the trapezoid body. Detected in the olfactory bulb; red nucleus; facial nucleus; pontine nucleus; oculomotor nucleus; substantia nigra; deep cerebellar nuclei; vestibular nucleus; and the thalamus. Detected in hippocampal CA1; CA2; and CA3 regions; the dentate gyrus; supraoptic nucleus; hypothalamus; dorsal root ganglion; and cortical layers II; III; and V. Detected in striatum cholinergic interneurons.
DOI ID
10.1523/jneurosci.23-37-11681.2003; 10.1002/cne.20462; 10.1523/jneurosci.3372-05.2006; 10.1523/jneurosci.0551-07.2007; 10.1016/j.celrep.2017.09.088
RefSeq
NP_942057.1